stroke hemiplegia
Conditions
Interventions
control subjects:Sham TMS & Sham Sound
experimental group:AM-PAS
Sponsors
Tongji Hospital, Tongji Medical College ,Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 18 and 80 years, both male and female eligible; 2.First-ever stroke confirmed by MRI or CT as unilateral stroke, with disease duration of 1-6 months; 3.Baseline upper limb motor function: Active wrist dorsiflexion >10° ; Thumb abduction/extension >10° ; Extension >10° in at least two other fingers; 4.egree of limb impairment: Unilateral limb weakness; Fugl-Meyer Assessment for Upper Extremity (FM-UE) score =22; 9.Good tolerance to sudden auditory stimuli at 114 dB; 10.Willing to provide written informed consent;
Exclusion criteria
Exclusion criteria: 1.History of prior stroke; 2.Severe upper limb spasticity (Modified Ashworth Scale [MAS] score >=3); 3.Other conditions significantly affecting upper or lower limb function, including: Joint contractures; Muscle contractures; Frozen shoulder (adhesive capsulitis); Fractures; Arthritis; Local skin ulcers or pressure sores; 4.Moderate to severe cognitive impairment or history of major psychiatric/physiological disorders; 5.Poorly controlled hypertension (systolic blood pressure =185 mmHg or diastolic blood pressure >=110 mmHg despite medication at randomization); 6.Botulinum toxin injection in the upper limb within 3 months prior to randomization or anticipated need for injection before the final follow-up; 7.Use of medications that may interfere with TMS during the study period; 8.History of hypersensitivity or intolerance to auditory stimuli; 9.Contraindications to TMS or MRI; 10.History of epilepsy or seizures within the past three months; electroencephalogram (EEG) showing epileptiform discharges (for high-risk individuals for TMS);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FMA-UE; | — |
Secondary
| Measure | Time frame |
|---|---|
| functional near-infrared spectroscopy;MVC;rs-fMRI;MEP;grip strength; | — |
Countries
China
Contacts
Public ContactHan Xiaohua
Tongji Hospital, Tongji Medical College ,Huazhong University of Science and Technology
Outcome results
None listed