peritoneal dialysis
Conditions
Interventions
treatment group:Intervention Name: High-Frequency Tidal Peritoneal Dialysis (TPD) Intervention Medicinal Product: Glucose-containing Peritoneal Dialysis Solution Intervention Device: Automated Periton
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 75 years, diagnosed with stage 5 chronic kidney disease. 2.Under stable maintenance peritoneal dialysis for at least 3 months. 3.Peritoneal transport function and dialysis adequacy assessed within 1 month prior to enrollment, with weekly Kt/V less than 1.7 indicating inadequate dialysis under the current regimen.
Exclusion criteria
Exclusion criteria: 1.Positive serological markers for active infectious diseases including hepatitis B, hepatitis C, HIV and syphilis. 2.Presence of intra-abdominal infection. 3.History of peritonitis within the preceding month. 4.Intraperitoneal tumor metastasis. 5.Severe malnutrition or coagulation disorders. 6.Inability to maintain supine position. 7.Refusal to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| electrolytes;glucose; | — |
Secondary
| Measure | Time frame |
|---|---|
| ktv;alpha-smooth muscle actin;Interleukin-6 (IL-6);Type I collagen;Total protein;Creatinine;Monocyte Chemoattractant Protein-1 (MCP-1);E-cadherin;Vascular Endothelial Growth Factor;Albumin;N-terminal pro-B-type natriuretic peptide (NT-proBNP);beta2-microglobulin;Fibronectin;Other uremic toxins;Transforming Growth Factor-beta;Urea;C-reactive protein (CRP); | — |
Countries
China
Contacts
Public ContactLiao Ruoxi
West China Hospital of Sichuan University
Outcome results
None listed