Radiotherapy- and Immunotherapy-Related Pneumonitis Symptoms
Conditions
Interventions
Observation group:None
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 75 years; 2. Pathologically or cytologically confirmed lung cancer; 3. Received thoracic radiotherapy and immunotherapy, with a clearly defined temporal relationship between the two treatments; 4. Availability of at least the following CT imaging studies: a baseline CT scan before immunotherapy; a radiotherapy planning/simulation CT scan; and a follow-up CT scan after completion of treatment or a CT scan obtained at the onset of pneumonitis.
Exclusion criteria
Exclusion criteria: 1. Active infectious pneumonia or uncontrolled lower respiratory tract infection prior to initiation of immunotherapy or radiotherapy; 2. Grade >=2 respiratory failure, requirement for long-term oxygen therapy, or severe pulmonary dysfunction prior to initiation of immunotherapy or radiotherapy that may confound the assessment of subsequent pneumonitis events; 3. Active interstitial lung disease (ILD), idiopathic pulmonary fibrosis, or other clearly diagnosed fibrotic interstitial lung diseases; 4. Missing imaging at key time points, including the absence of a baseline CT scan before immunotherapy or a radiotherapy planning/simulation CT scan (4DCT).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of early severe (Grade >=3) pneumonitis; | — |
Secondary
| Measure | Time frame |
|---|---|
| The predictive efficacy of the AUC value of the prediction model for the probability of pneumonia occurrence; | — |
Countries
China
Contacts
Public ContactBai Xue
Southern Medical University Southern Hospital
Outcome results
None listed