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A Real-World Study on the Safety and Efficacy of Transcranial Time-Interference Stimulation (TI) in Patients with Multiple System Atrophy (Cerebellar Type)

A Real-World Study on the Safety and Efficacy of Transcranial Time-Interference Stimulation (TI) in Patients with Multiple System Atrophy (Cerebellar Type)

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600129206
Enrollment
Unknown
Registered
2026-08-01
Start date
2026-08-05
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple system atrophy (cerebellar type)

Interventions

Transcranial temporal interference stimulation (TI) therapy group:None

Sponsors

The Second Qilu Hospital of Shandong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Meets the clinical diagnostic criteria for multiple system atrophy (cerebellar type), with MRI showing cerebellar involvement; 2. SARA score >=3; 3. Disease duration of at least 6 months with stable condition over the past 3 months; 4. Stable vital signs, able to cooperate with treatment and assessment; 5. Voluntarily signed informed consent form; 6. Aged 18-75 years, with no sex restriction.

Exclusion criteria

Exclusion criteria: 1. Intracranial metallic foreign bodies or implants, or skull defects; 2. Severe neurological disorders (e.g., epilepsy, traumatic brain injury, post-neurosurgical conditions); 3. Severe cognitive impairment or psychiatric disorders; 4. Receipt of neuromodulation therapy or participation in related clinical trials within the past 3 months; 5. Severe dysfunction of vital organs such as the heart, liver, and kidneys; coagulation disorders; or Individuals deemed unsuitable for enrollment by the investigator.

Design outcomes

Primary

MeasureTime frame
Scale for the Assessment and Rating of Ataxia;

Secondary

MeasureTime frame
Adverse Event Incidence Rate;Activities of Daily Living Score;Berg Balance Score;

Countries

China

Contacts

Public ContactDun Zhiping

The Second Qilu Hospital of Shandong University

dunzhp@163.com+86 531 67726125

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Aug 10, 2026