Acquired muscle weakness in the intensive care unit
Conditions
Interventions
ICU non-sepsis control group:None
Surgical patients with sepsis:None
Non-septic abdominal surgery patients:None
Sponsors
Suining Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients admitted to the ICU; 2.Sepsis group: Meets the diagnostic criteria of Sepsis-3, that is, there is a definite or suspected infection, and the SOFA score is increased by >= 2 points compared to the baseline level; 3.Non-sepsis ICU control group: Patients who were hospitalized in the ICU during the same period, without any clear evidence of infection and not meeting the diagnostic criteria for sepsis; 4.Histological study of the sepsis group: Due to intestinal perforation, peritonitis, etc., emergency abdominal surgery was performed, and the diagnosis of sepsis was met; 5.Histological study control group: Patients who underwent abdominal surgery for non-sepsis-related reasons;
Exclusion criteria
Exclusion criteria: Exclusion Criteria for Clinical Cohort Study 1.Those who have been previously diagnosed with neuromuscular diseases, such as myasthenia gravis, muscular dystrophy, motor neuron disease, severe peripheral neuropathy, etc. 2.Those who have been bedridden for a long time, have severe limitations in limb movement, or already have obvious muscle atrophy before enrollment; 3.Those who have recently suffered lower limb injuries, undergone lower limb surgeries, had amputations, or have any other conditions that affect the ultrasound measurement of the rectus femoris muscle; 4.Patients with terminal malignant tumors, severe chronic wasting diseases, or those who are expected to be unable to complete basic follow-up within a short period of time; 5.Those who have been using large doses of glucocorticoids, immunosuppressants or other drugs that may significantly affect the metabolism of skeletal muscles for a long time; 6. Pregnant or breastfeeding patients; 7. Other situations that the researcher thinks are not suitable for enrollment. Exclusion Criteria for Histological Verification Substudy 1. Patients from whom abdominal wall skeletal muscle tissue cannot be safely obtained during surgery; 2. When the surgeon believes that sampling may increase bleeding, infection, surgery time, or other surgical risks; 3. Sampling sites with obvious infection, necrosis, tumor involvement, severe contamination, or tissue conditions unsuitable for testing; 4. Patients with clear neuromuscular diseases, long-term bedridden, or severe chronic wasting conditions that may significantly affect muscle tissue results; 5. Patients or their legal representatives who refuse tissue sample collection; 6. Other situations that the researcher believes are not suitable for inclusion in histological verification.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The rate of decrease in the thickness of the rectus femoris muscle; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence rate of ICU-AW; | — |
Countries
China
Contacts
Public ContactHong Liu
Suining Central Hospital
Outcome results
None listed