Colonic diverticulitis
Conditions
Interventions
Control group:Endoscopic clip closure
Experimental group:Endoscopic submucosal injection of polidocanol
Sponsors
The Second Affiliated Hospital of the Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18–80 years, with no restriction on sex; 2.Colonic diverticula confirmed by abdominal computed tomography (CT) and/or colonoscopy, with at least one colonic diverticulum-related complication—such as diverticulitis, diverticular bleeding, or fecalith impaction within a colonic diverticulum—confirmed by clinical, radiologic, and/or endoscopic assessment; 3.Presence of a clearly identifiable target diverticulum considered suitable for local endoscopic intervention by an endoscopist; 4.Deemed able to tolerate colonoscopy and endoscopic intervention following comprehensive clinical evaluation; 5.Voluntary participation in the study, willingness and ability to complete the treatment, follow-up examinations, and scheduled follow-up visits, and provision of written informed consent.
Exclusion criteria
Exclusion criteria: 1.Severe dysfunction of major organs or systems, including the heart, lungs, liver, kidneys, or nervous system, resulting in an inability to tolerate bowel preparation, anesthesia or sedation, colonoscopy, or endoscopic intervention despite comprehensive evaluation, or an unacceptably high procedural risk; 2.Diffuse peritonitis, suspected or confirmed gastrointestinal perforation, intestinal obstruction, toxic megacolon, uncontrolled severe infection, or other acute or critical conditions in which colonoscopy or endoscopic treatment is considered inappropriate; 3.Uncorrected coagulation disorders, active bleeding disorders, or current use of anticoagulant or antiplatelet agents that cannot be appropriately adjusted or discontinued during the periprocedural period; 4.Other colorectal lesions requiring priority management, such as suspected or confirmed colorectal malignancy, active severe inflammatory bowel disease, or intestinal conditions requiring emergency surgery, which may interfere with the implementation of the study intervention or the assessment of safety or efficacy; 5.Pregnant or breastfeeding women; 6.Participation within the previous 3 months in another clinical trial that may affect the safety or efficacy assessments of the present study; 7.Any other condition considered by the investigator to render the participant unsuitable for enrollment, based on participant safety or the reliability of the study results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment success rate for colonic diverticular complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of treatment-related adverse events;Clinical recurrence rate; | — |
Countries
China
Contacts
Public ContactChaoqiang Fan
The Second Affiliated Hospital of the Army Medical University
Outcome results
None listed