renal cell carcinoma
Conditions
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Patients with clinical T3a renal cell carcinoma who are scheduled to undergo surgical treatment at our center; 2.Patients aged 18–75 years; 3.Imaging findings consistent with renal cell carcinoma, with suspected T3a-related features such as perinephric fat invasion, renal sinus fat invasion, invasion of the renal vein or its branches, or collecting system invasion; 4.No evidence of distant metastasis on preoperative evaluation; 5.Patients who voluntarily participate in the study, provide written informed consent, and are willing to complete the scheduled follow-up.
Exclusion criteria
Exclusion criteria: 1.Preoperative imaging indicating tumor extension into the inferior vena cava, beyond the renal fascia, or into adjacent organs, suggesting clinical stage T3b, T3c, or T4 disease; 2.Presence of distant metastasis or definite unresectable lymph node metastasis; 3.A history of surgery on the ipsilateral kidney; suspected severe adhesion between the ipsilateral kidney and surrounding tissues; or special conditions such as a solitary kidney, bilateral renal tumors, or severe chronic renal insufficiency; 4.Presence of another concurrent malignant tumor; 5.Underlying medical conditions that preclude tolerance of surgery; 6.Inability to understand the study, provide written informed consent, or complete the required follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Estimated glomerular filtration rate (eGFR);Progression-free survival (PFS);Cancer-specific survival (CSS);Overall survival (OS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Operative time;Intraoperative blood loss;Perioperative blood transfusion;Conversion to open surgery or intraoperative change in surgical approach;length of stay;Duration of postoperative drainage;Postoperative complications and Clavien–Dindo classification;Pathological invasion pattern; | — |
Countries
China
Contacts
Public ContactLiu Kan
Chinese PLA General Hospital
Outcome results
None listed