perioperative neurocognitive disorder, PND
Conditions
Interventions
Esketamine group:During anesthesia induction, 0.25 mg/kg of esketamine was administered. Subsequently, it was continuously infused intravenously at a rate of 0.25 mg/(kg·h) until 30 minutes before the
Control group:Administer the same volume of normal saline by intravenous infusion in the same manner
Sponsors
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age over 65 years old; 2.ASA classification of the American Society of Anesthesiologists as grade II or III; 3.Elective general anesthesia for thoracoscopic lung resection; 4.Agree to participate in this trial and sign a written informed consent form;
Exclusion criteria
Exclusion criteria: 1. There is unstable hypertension and a history of heart disease; 2. Severe abnormalities in liver and kidney functions; 3. Patients who have undergone chemotherapy before the surgery; 4. Those with a history of chronic pain or long-term use of painkillers; 5. Those with mental disorders or who cannot cooperate or communicate; 6. Those with contraindications or allergies to esketamine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral tissue oxygenation during 20 minutes of single-lung ventilation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in inflammatory factors;The change in postoperative anxiety and depression states;The incidence of delirium and cognitive dysfunction;Pain score; | — |
Countries
China
Contacts
Public ContactLi Jingjin
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Outcome results
None listed