general anesthesia surgery
Conditions
Interventions
Propofol Group:Provide maintenance with propofol during surgery
Sevoflurane group:Provide maintenance with sevoflurane during surgery
Sponsors
North China University of Science and Technology Affiliated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–80 years, no gender restriction. 2. Planned elective surgery requiring tracheal intubation and intraoperative anesthesia maintenance under general anesthesia. 3. ASA classification I–III. 4. Expected surgery duration >=2 hours. 5. Able to understand the procedures and methods of this study, willing to sign the informed consent form, and strictly comply with the clinical research protocol to complete this study.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery or inability to complete preoperative evaluation. 2. Known allergy/contraindication to remifentanil, sevoflurane, or study-related drugs. 3. Severe cardiac or pulmonary dysfunction (such as decompensated heart failure, severe arrhythmia, severe respiratory failure) deemed unsuitable for enrollment by the investigator. 4. Severe hepatic or renal dysfunction (such as Child-Pugh C, or end-stage renal disease requiring dialysis). 5. Obvious preoperative neuropsychiatric abnormalities or severe cognitive impairment that prevents completion of postoperative assessments and follow-ups. 6. Pregnant or breastfeeding women. 7. Participation in other interventional clinical trials in the past 3 months that may affect the outcomes of this study. 8. Investigator judges poor compliance, unable to complete follow-up according to the protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total Quality of Recovery-15 score at 24 hours after surgery; | — |
Countries
China
Contacts
Public ContactMa Wei
North China University of Science and Technology Affiliated Hospital
Outcome results
None listed