traumatic brain injury
Conditions
Interventions
Sponsors
The Army Specialized Medical Center of the People's Liberation Army of China
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for the TBI group: (1) Clinically diagnosed as traumatic brain injury based on medical history and imaging signs from the Trauma Biopsy Repository; (2) Age ranging from 18 to 80 years old. 2. Inclusion criteria for the non-brain injury from trauma group: (1) Age ranging from 18 to 80 years old; (2) Clinically diagnosed as trauma patients (except for brain trauma) based on medical history and imaging signs; (3) Visited the Department of War Trauma Medicine of our hospital within 24 hours after the injury; (4) The patient or their legal guardian voluntarily signed the informed consent form. 3. Inclusion criteria for the healthy control group: (1) Healthy individuals matched with the case group in terms of age and gender; (2) No previous history of neurological diseases (such as cerebral infarction, cerebral hemorrhage, cognitive impairment-related diseases); (3)Voluntarily signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with previous neurological disorders (such as cerebral infarction, cerebral hemorrhage, and diseases related to cognitive impairment); 2. Severe coronary heart disease, heart dysfunction, atrial fibrillation and other heart diseases; severe liver and kidney dysfunction; severe blood system diseases, coagulation disorders; advanced malignant tumors, etc.; 3.Those who violated the research rules, had poor compliance or refused to participate in this project.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic and predictive performance: area under the curve (AUC), accuracy, sensitivity, specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| neurofilament light chain;total tau;glial fibrillary acidic protein;ubiquitin carboxyl-terminal hydrolase L1; | — |
Countries
China
Contacts
Public ContactYanjiang Wang
The Army Specialized Medical Center of the People's Liberation Army of China
Outcome results
None listed