Acute anterior circulation large-core ischemic stroke (ASPECTS 0-5 or core infarct volume > 50ml)
Conditions
Interventions
Mechanical thrombectomy group:None
standard medical treatment group:None
Sponsors
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >=18 years old; 2.Patients with acute ischemic stroke with onset within 24 hours from the last normal time received endovascular therapy or optimal medical therapy; 3.The presence of occlusion of internal carotid artery or M1 / M2 segment of middle cerebral artery was confirmed by CT angiography, magnetic resonance angiography or digital subtraction angiography; 4.A baseline ASPECTS score of 0-5 or a large cerebral infarct core volume >= 50ml (defined as relative cerebral blood flow < 30% on CT perfusion imaging) was assessed on the basis of noncontrast CT (NCCT); 5.Informed consent was obtained.
Exclusion criteria
Exclusion criteria: 1.Acute intracranial hemorrhage was confirmed by CT or MRI. 2.Baseline imaging examination showed that there was mass effect, accompanied by ventricular compression, midline shift, or cerebral herniation. 3.Pregnant or childbearing age women, urine or serum ß-human chorionic gonadotropin test may be positive; 4.Severe bleeding tendency, severe heart, liver or kidney disease, or sepsis; 5.Terminal illness with life expectancy less than 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Distribution of 90-day mRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| 90-day mRS 0-3;death at 90 days;Symptomatic intracerebral hemorrhage; | — |
Countries
China
Contacts
Public ContactGuangdong Lu
The First Affiliated Hospital with Nanjing Medical University
Outcome results
None listed