Motor dysfunction after supratentorial stroke
Conditions
Interventions
SSVEP-BCI Group:SSVEP-BCI-based coordinated upper and lower limb training plus conventional rehabilitation
Control Group:Conventional coordinated training plus conventional rehabilitation
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. First-ever supratentorial stroke, with onset within 2 weeks to 3 months, aged 40-75 years. 2. Presence of moderate to severe upper extremity motor dysfunction due to upper motor neuron injury, with Fugl-Meyer Upper Extremity (FMA-UE) score between 10 and 50, and Fugl-Meyer Lower Extremity (FMA-LE) score between 10 and 28. 3. Alert, with cognitive function meeting basic training requirements. The MMSE cutoff scores adjusted by education years are set as: illiterate >17, primary school education >20, secondary school and above >24. Visual acuity/corrected vision must meet the requirements for SSVEP-BCI training. 4. The patient or their legal guardian provides informed consent and agrees to cooperate with the study and follow-up.
Exclusion criteria
Exclusion criteria: 1. Severe comorbidities: severe cognitive impairment, limb contracture or deformity, severe cardiac/pulmonary/hepatic/renal insufficiency, malignant tumor, active mental illness, history of epilepsy; 2. Severe visual field defect or visual neglect that precludes participation in BCI tasks; 3. Modified Ashworth Scale grade =3 in the primary muscle groups of the affected limb (elbow flexors/extensors, knee flexors/extensors); 4. Concurrent participation in another interventional clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Barthel Index;Fugl-Meyer Assessment Total Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional near-infrared spectroscopy (fNIRS) assessment of brain functional reorganization;Holden;Fugl-Meyer Assessment Lower Extremity Score;Ashworth;Modified Rankin Scale;Surface electromyography (sEMG) assessment of muscle synergy patterns;Electroencephalography (EEG) assessment of SSVEP response quality and brain network functional connectivity;Fugl-Meyer Assessment Upper Extremity Score;Berg Balance Scale;10MWT; | — |
Countries
China
Contacts
Public ContactQiao Jin
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed