Depression disorder
Conditions
Interventions
Adolescent group:Esketamine 0.2mg/kg was infused by a peripheral intravenous pump
The middle and elderly group:Esketamine 0.2mg/kg was infused by a peripheral intravenous pump
Sponsors
Changzhou Second People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Depressive disorder without psychotic symptoms was diagnosed clinically by a licensed psychiatrist and met the Diagnostic and Statistical Manual of Mental Disorders, Fifth edition (DSM-5); 2.The total score of Montgomery Depression Scale (MADRS) was 22 or higher; 3.Understand the content of the study and sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Patients with other severe mental disorders conforming to DSM-5 diagnostic criteria, including schizophrenia, schizoaffective disorder, bipolar disorder, etc; 2.History of severe physical or brain organic diseases, traumatic brain injury and epilepsy; 3.History of drug, alcohol, or other psychoactive substance abuse; 4.Having metal in the body, such as a pacemaker or electrodes in the brain; 5.Previous history of allergy to anesthetics; 6.Women who are pregnant or breastfeeding or who plan to become pregnant; 7.Patients with contraindications of magnetic resonance imaging scanning or factors affecting imaging quality, such as cardiac pacemaker, cardiovascular and cerebrovascular metal stents, cochlear implants, metal dentures, etc; 8.Other conditions deemed inappropriate by the investigator;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montgomery Depression Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pittsburgh Sleep Quality Index scale;Sleep monitoring; | — |
Countries
China
Contacts
Public ContactWu Zhouquan
Changzhou Second People's Hospital
Outcome results
None listed