High-altitude population with pulmonary function deterioration
Conditions
Interventions
Gold Standard:Pulmonary function assessed by chest CT: FEV1/FVC < 0.7 (i.e., 70%).
Index test:To measure the regional time constant (t) and its derived parameters (t_med, t_iqr, t_prod, etc.) using EIT
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80 years, both sexes; 2. Continuous residence in high-altitude areas (altitude >= 2,500 m) for at least 5 years; 3. Participants must have been enrolled in the high-altitude epidemiological survey performed by the Center for High-Altitude Medicine at West China Hospital of Sichuan University, and must be capable of cooperating to complete forced spirometry; 4. Participants must voluntarily agree to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Inability/unfitness for EIT or conditions interfering with EIT (e.g., pacemaker/defibrillator). 2. Inability to complete spirometry: myocardial infarction/shock within 3 months; severe heart failure/unstable angina within 4 weeks; uncontrolled hypertension (SBP>200 or DBP>100 mmHg); severe hyperthyroidism, etc. 3. Vulnerable groups: psychiatric disorders, cognitive impairment, critical illness, illiteracy, pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EIT-measured regional time constant (t) and its derived parameters (t_med, t_iqr, t_prod, etc.);Diagnostic test evaluation indicators of EIT for pulmonary function abnormalities, such as accuracy, sensitivity, specificity, PPV, NPV, FPR, FNR, and AUC etc., were assessed using chest CT as the gold standard; | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between EIT parameters and spirometry-derived pulmonary function indices using Spearman's or Pearson's correlation coefficient;Correlation between EIT parameters and impulse oscillometry (IOS) parameters using Spearman's or Pearson's correlation coefficient;Differences in EIT parameters among subgroups defined by altitude, duration of residence, smoking status, and sex;Correlation between impulse oscillometry (IOS) parameters (Z5, R5, R20, X5, Fres, etc.) and spirometric small airway parameters (MMEF, FEF25–75%, etc.) using Spearman's or Pearson's correlation coefficient; | — |
Countries
China
Contacts
Public ContactFengming Luo
West China Hospital of Sichuan University
Outcome results
None listed