Postpartum depression and post-operative pain in patients with cesarean section
Conditions
Interventions
Trial Group:0.125 mg/kg esketamine combined with hydrochloric acid ropivacaine 100 mg diluted to total volume 40 ml for ultrasound-guided bilateral TAP block.
Control Group:Hydrochloric acid ropivacaine 100 mg diluted to total volume of 40 ml and performed bilateral TAP block under ultrasound guidance.
Sponsors
Linyi Maternal and Child Health Care Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Age must be =18 years old and =45 years old; 2. Singleton term pregnancy; 3. Scheduled elective cesarean delivery; 4. ASA physical status I–III; 5. Able to understand and complete EPDS and VAS assessments; 6. Preoperative EPDS score <9 points; 7. Willing to participate and sign written informed consent.
Exclusion criteria
Exclusion criteria: 1. Allergy to esketamine, ketamine, ropivacaine, or other amide local anesthetics; 2. Severe hepatic, renal, or cardiac dysfunction; 3. Uncontrolled hypertensive disorders of pregnancy; 4. History of psychiatric disorders, or current use of antidepressants, antipsychotics, or sedative-hypnotics; 5. Chronic pain or long-term opioid use; 6. Contraindications to TAP block or neuraxial anesthesia; 7. Conversion to general anesthesia during surgery; 8. Serious perioperative complications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EPDS score on postpartum day 30; | — |
Secondary
| Measure | Time frame |
|---|---|
| EPDS score on preoperative day 1 ;EPDS score on postoperative day ; EPDS score on postoperative day 4;6h post-operative VAS pain score;12h post-operative VAS pain score;24h post-operative VAS pain score;48h post-operative VAS pain score;6h post-operative number of PCIA boluses;12h post-operative number of PCIA boluses;24h post-operative number of PCIA boluses;48h post-operative number of PCIA boluses;Remedies for pain relief at 6h after surgery (50mg of tramadol, daily total amount not exceeding 400mg);Remedies for pain relief at 12h after surgery (50mg of tramadol, daily total amount not exceeding 400mg);Remedies for pain relief at 24h after surgery (50mg of tramadol, daily total amount not exceeding 400mg);Remedies for pain relief at 48h after surgery (50mg of tramadol, daily total amount not exceeding 400mg);Adverse reactions 6 hours after surgery: including nausea, vomiting, dizziness, itchy skin, nightmares;Adverse reactions 12 hours after surgery: including nausea, vomiting, dizziness, itchy skin, nightmares;Adverse reactions 24 hours after surgery: including nausea, vomiting, dizziness, itchy skin, nightmares;Adverse reactions 48 hours after surgery: including nausea, vomiting, dizziness, itchy skin, nightmares; | — |
Countries
China
Contacts
Public ContactChen Bin
Linyi Maternal and Child Health Care Hospital
Outcome results
None listed