Hypertrophic olivary degeneration after brainstem or cerebellar hemorrhage
Conditions
Interventions
Group A: GMT injury positive and HOD positive Group B: GMT injury positive and HOD negative Group C: GMT injury negative and HOD negative:None
Sponsors
Mindong Hospital of Ningde City
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age 18 years or older; 2.Diagnosed with brainstem hemorrhage or cerebellar hemorrhage by cranial CT or MRI; 3.Able to complete MRI and DTI examinations within the predefined study time window after onset; 4.Complete clinical and imaging data are available, and the participant is able to complete follow-up and neurological functional assessments; 5.Written informed consent is obtained from the participant or legal representative;
Exclusion criteria
Exclusion criteria: 1.Previous diagnosis of hypertrophic olivary degeneration or pre-existing olivary lesions; 2.Severe traumatic brain injury, brain tumor, encephalitis, demyelinating disease, or other disorders that may affect the assessment of the brainstem, cerebellum, or related neural pathways; 3.Contraindications to MRI, such as a pacemaker, incompatible metallic implants, or severe claustrophobia; 4.Poor-quality imaging data that cannot be used for DTI post-processing or fiber tractography analysis; 5.Severe dysfunction of major organs or other serious conditions that preclude completion of follow-up; 6.Pregnancy or lactation; 7.Other conditions considered unsuitable for participation by the investigators;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of HOD at 6-month follow-up;Early quantitative DTI parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Balance Scale score;modified Rankin Scale (mRS) score;Activities of Daily Living (ADL) scale score;Water Swallow Test (WST); | — |
Countries
China
Contacts
Public ContactLin Lin
Mindong Hospital of Ningde City
Outcome results
None listed