Breast cancer with axillary lymph node metastasis
Conditions
Interventions
Gold Standard:Pathological result of lymph node biopsy
Index test:Ultrasound-based radiomics model for predicting lymph node metastasis risk (extracting high-dimensional features including texture, morphology, and intensity distribution from ultrasound im
Sponsors
chongqing university cancer hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years; 2.Clinically or radiologically suspected breast cancer and scheduled to undergo regional lymph node biopsy; 3.Preoperative lymph node ultrasound completed with adequate image quality for radiomics analysis; 4.Residual tissue sample available for research after fulfilling pathological diagnosis requirements; 5.Pathological result clearly defines metastatic or non-metastatic lymph node; 6.Subject voluntarily agrees to participate and signs written informed consent;
Exclusion criteria
Exclusion criteria: 1.Incomplete standardized ultrasound examination or poor image quality that cannot be used for radiomics analysis; 2.Insufficient biopsy sample leaving no residual tissue for research after pathological diagnosis; 3.Pathological result cannot definitively determine lymph node metastasis status; 4.Prior anti-tumor therapy that may affect lymph node metabolic status (e.g., neoadjuvant chemotherapy, targeted therapy, radiotherapy) and considered unsuitable for inclusion by the investigator; 5.Concurrent severe infection, acute exacerbation of metabolic disease, or other conditions that may significantly affect metabolomics results; 6.Incomplete clinical data that cannot meet study analysis requirements; 7.Unwilling to participate in the study or withdrawal of informed consent during the study process;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lymph node metastasis status;Accuracy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Specificity;Sensitivity; | — |
Countries
China
Contacts
Public ContactFang Li
chongqing university cancer hospital
Outcome results
None listed