cardiac surgery-associated acute kidney injury
Conditions
Interventions
CSA-AKI group & non-CSA-AKI group:None
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or older; 2. Scheduled for elective cardiac surgery; 3. Surgery performed under cardiopulmonary bypass (CPB); 4. Able to complete preoperative stool and blood sample collection independently; 5. The patient and their family members voluntarily participate in this study, agree to the collection of preoperative stool samples, blood samples and clinical data, cooperate with follow-up visits, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with end-stage renal disease or dependence on renal replacement therapy before surgery; 2. Patients with a preoperative estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73m^2 or severe chronic kidney disease (CKD stage 4–5); 3. Patients with a history of renal transplantation or unilateral nephrectomy; 4. Patients who received antibiotic treatment within 4 weeks before surgery; 5. Patients who took probiotic or prebiotic preparations within 4 weeks before surgery; 6. Patients with a previous history of intestinal surgery, such as colectomy and small bowel resection; 7. Patients with active inflammatory bowel disease, chronic diarrhea or constipation requiring pharmacological intervention; 8. Patients with preoperative intestinal obstruction, gastrointestinal bleeding, or those requiring fasting for more than 24 hours; 9. Patients undergoing emergency surgery (time from admission to surgery < 24 hours), or those unable to complete preoperative informed consent, dietary investigation and baseline sample collection; 10. Patients who received mechanical bowel preparation (e.g., enema) within 24 hours before surgery; 11. Patients with preoperative active infection or sepsis; 12. Patients treated with preoperative glucocorticoids or immunosuppressants (excluding routine doses); 13. Patients who died intraoperatively or within 24 hours postoperatively, or those who could not complete the evaluation of the primary outcome (postoperative 7-day acute kidney injury [AKI]); 14. Female patients who are pregnant, lactating or in menstruation; 15. Patients complicated with gastrointestinal malignant tumors or receiving systemic chemotherapy, targeted therapy or abdominal radiotherapy; 16. Patients with severe liver disease (Child-Pugh grade B or above).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Predictive efficacy of microbiota-metabolites for CSA-AKI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of acute kidney injury (AKI) within 7 days after cardiac surgery;AKI severity;Persistent AKI (>=48 hours);Total postoperative hospital stay,ICU stay duration;In-hospital mortality;90-day postoperative mortality; | — |
Countries
China
Contacts
Public ContactChunhua Yu
Peking Union Medical College Hospital
Outcome results
None listed