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Exploring the induction of ferroptosis in lung cancer cells mediated by genistein through the TP53/SLC7A11/GPX4 axis based on network pharmacology and machine learning

Exploring the induction of ferroptosis in lung cancer cells mediated by genistein through the TP53/SLC7A11/GPX4 axis based on network pharmacology and machine learning

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600129087
Enrollment
Unknown
Registered
2026-07-30
Start date
2026-07-30
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lung cancer

Interventions

Sponsors

The First Affiliated Hospital of Dalian Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patients in the lung cancer group were required to have pathological results and histological subtype confirmed by histological or cytological examination, clinical staging determined per the 8th edition IASLC TNM classification, and a diagnosis of primary lung adenocarcinoma established by preoperative biopsy or intraoperative frozen section. 2. Complete clinical baseline information, imaging data, and histopathological information were available. 3. Patients were required to have good compliance and to be able to comply with regular follow-up assessments. 4. Both sexes, age 18 to 75 years.

Exclusion criteria

Exclusion criteria: 1. Patients who are pregnant, postpartum, or currently lactating; 2. Patients with a history of other malignant tumors; 3. Patients complicated by failure of other major organs; 4. Patients with autoimmune diseases, those on long-term medications that affect immune function, or those who have used or taken immune-enhancing foods or medications over a long period or within the past 2 months. 5. Patients who refused to provide written informed consent;

Design outcomes

Primary

MeasureTime frame
TP53/SLC7A11/GPX4;

Countries

China

Contacts

Public ContactZhao Shilei

The First Affiliated Hospital of Dalian Medical University

bbstnt@126.com+86 411 8363 5963

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Aug 10, 2026