Anxiety, Depression
Conditions
Interventions
Intervention Group:Receive piTBS intervention with high frequency and short duration (one session per day over 2 consecutive weeks)
Control Group:Receive sham stimulation under identical conditions
Sponsors
University of Electronic Science and Technology of China
Eligibility
Sex/Gender
All
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18–30 years, of either sex, right-handed, and currently enrolled as a university student; 2.Has a total score of >=14 on the Beck Depression Inventory (BDI) at initial screening; 3.Following assessment by a psychiatrist using the Structured Clinical Interview for DSM-5 Disorders (SCID-5), meets the study-defined operational criteria for subthreshold depression (StD), characterized by the presence of depressive symptoms without meeting the DSM-5 diagnostic criteria for major depressive disorder (MDD) or bipolar disorder; 4.Has at least one core depressive symptom, namely depressed mood or diminished interest or pleasure, persisting for at least 2 weeks; 5. Experiences subjective distress or mild-to-moderate impairment in social functioning; 6. Voluntarily agrees to participate in the study and provides written informed consent.
Exclusion criteria
Exclusion criteria: 1.Meets the DSM-5 diagnostic criteria for major depressive disorder (MDD), bipolar disorder, or any other mental disorder, as determined by the SCID-5 interview; 2. Has a severe medical condition or neurological disorder, such as epilepsy, or a history of traumatic brain injury; 3.Has any contraindication to MRI scanning, such as metallic implants or claustrophobia; 4.Has a history of alcohol or other substance abuse within the past 6 months; 5.Is receiving antidepressant medication or psychotherapy during the intervention period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total score of the Beck Depression Inventory (BDI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Magnetic resonance imaging characteristic; | — |
Countries
China
Contacts
Public ContactJiao Li
University of Electronic Science and Technology of China
Outcome results
None listed