Target disease: Cardiopulmonary arrest (Out-of-hospital cardiac arrest)
Conditions
Interventions
Delayed Intervention Group:None
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients aged 18 to 70 years old; 2. Suffered from out-of-hospital cardiac arrest (OHCA), with witnesses at the time of cardiac arrest, received bystander cardiopulmonary resuscitation (CPR), and no-flow time < 5 minutes; 3. No restoration of spontaneous circulation (ROSC) after sustained conventional cardiopulmonary resuscitation (CCPR) for more than 15 minutes, or hemodynamic instability/recurrent cardiac arrest after ROSC, requiring extracorporeal cardiopulmonary resuscitation (ECPR) treatment; 4. Time from cardiac arrest to hospital admission < 30 minutes, and estimated time from admission to successful ECMO bypass < 60 minutes; 5. Clinically judged that the cause of cardiac arrest is reversible (such as cardiogenic, pulmonary embolism, etc.); 6. Arterial blood lactic acid level < 18 mmol/L before ECMO catheterization; 7. The patient's family members signed the informed consent form for ECPR clinical treatment.
Exclusion criteria
Exclusion criteria: 1. With irreversible brain injury, such as large-area cerebral infarction, intracranial hemorrhage, etc.; 2. Complicated with end-stage diseases, such as advanced tumor, multiple organ failure, etc.; 3. With active massive hemorrhage, such as traumatic hemorrhage, massive upper gastrointestinal bleeding, intracranial hemorrhage, etc.; 4. The patient or family members explicitly refused active clinical treatment and ECPR-related interventions; 5. Severe aortic regurgitation confirmed by echocardiography, with regurgitation area > 5 cm².
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Discharge survival rate;Good neurological prognosis at discharge; | — |
Secondary
| Measure | Time frame |
|---|---|
| Post-resuscitation shock rate at ICU admission;Circulatory collapse rate within 24 hours;6-month survival rate;Good neurological prognosis at 6 months; | — |
Countries
China
Contacts
Public ContactSong Xiaodong
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed