Knee osteoarthritis (KOA)
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1.Those who meet the diagnostic criteria for knee osteoarthritis; 2.Those whose Kellgren/Lawrence (K/L) grade is determined to be 1 - 3 based on knee X - ray diagnosis and can independently complete walking at least 8 meters on flat ground and going up and down 8 steps; 3.Those whose VAS (Visual Analogue Scale) score for knee pain in the range of 0 - 10 cm is 7 >= VAS >= 3 cm in the week before the test; 4.Those without contraindications for magnetic resonance imaging; 5.Those who voluntarily participate in this project study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Individuals currently suffering from acute infectious diseases; those with obvious acute infectious symptoms within the past two weeks. 2.Those with clearly diagnosed insufficiency of vital organs such as the heart, lungs, liver, and kidneys, who are unable to tolerate exercise tests and training. 3.Those with diseases that affect motor control and gait patterns, including but not limited to: patients in the sequelae stage of stroke; neurological diseases such as Parkinson's disease, epilepsy, and spinal cord injury; those with clearly diagnosed cognitive impairment or dementia who cannot understand or cooperate with training and assessment; those with severe vestibular dysfunction and balance disorders. 4.Those with one of the following musculoskeletal system diseases: recent (<= 6 months) lower - limb fractures or severe soft - tissue injuries; inflammatory joint diseases such as rheumatoid arthritis and ankylosing spondylitis; severe degenerative diseases of the hip and ankle joints that significantly affect gait; those with obvious joint deformities or structural abnormalities leading to significantly abnormal movement patterns. 5.Those who have received intra - knee steroid (hormone) injection treatment within the past 3 months; those who have undergone arthroscopic surgery within the past 3 months; those who have received intra - knee hyaluronic acid injection treatment within the past 6 months; those who plan to undergo total knee arthroplasty (TKA) within the next 12 months. 6.Those who are participating in other clinical trials and may affect the evaluation of the primary outcome indicators of this study; those who are undergoing other systematic rehabilitation training programs (not the protocol of this study). 7.Those at a significantly high risk of falling, such as: those with a history of multiple falls within the past 6 months and unable to independently walk = 8 meters on flat ground; those with obvious limitations in joint range of motion and unable to complete the basic training action assessment process; those who cannot cooperate with assessment, training, and testing due to mental, psychological, language, or other reasons; those judged by the researcher to have safety hazards or insufficient compliance and thus are not suitable to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analog Scale(VAS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC);Three-dimensional gait analysis kinematic parameters;Three-dimensional gait analysis dynamic parameters;The Western Ontario and McMaster University Osteoarthritis Index;Magnetic Resonance Imaging of the Brain Function; | — |
Countries
China
Contacts
The Third Affiliated Hospital of Fujian University of Traditional Chinese Medicine; Fujian University of Traditional Chinese Medicine Rehabilitation Medical College