Stage IB3-IIA2 cervical cancer
Conditions
Interventions
Observation Group B(Blank microsphere uterine artery embolization combined with cisplatin + paclitaxel systemic intravenous chemotherapy):None
Observation Group A(Uterine artery embolization with drug-loaded microspheres containing cisplatin combined with systemic intravenous chemotherapy with paclitaxel):None
Sponsors
The First Affiliated Hospital,Sun Yat-sen University
Eligibility
Sex/Gender
Female
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The pathological diagnosis of cervical cancer is classified as locally advanced cervical cancer (IB3-IIA2) according to the FIGO staging system; 2.The age range is 18 to 80 years old; 3. Received DEB-TGA or concurrent radiotherapy treatment, and complete clinical and pathological information before and after the treatment.
Exclusion criteria
Exclusion criteria: 1. Severe effusion or pleural effusion; 2. Contraindications to cisplatin or paclitaxel; 3. Patients with severe mental disorders or severe cardiac, hepatic or renal dysfunction; 4. Patients complicated with other malignant tumors; 5. Uncontrollable diabetes or hypertension; 6. Contraindications for arterial perforation operation; 7. Presence of sepsis or severe infection; 8. Pregnant or lactating women; 9. Patients with severe coagulation dysfunction or anemia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective Response Rate ,Disease Control Rate;Safety and side effects of toxicity;Re-resection rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| 2-year Progression-Free Survival (PFS);Overall Survival (OS); | — |
Countries
China
Contacts
Public ContactJi Weiming
The First Affiliated Hospital,Sun Yat-sen University
Outcome results
None listed