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Reliability and Reproducibility of Non-Invasive Coronary Angiography-Based FFR (caFFR) Measurements: A Multi-Operator Study in Patients with Moderate to Severe Coronary Stenosis

Reliability and Reproducibility of Non-Invasive Coronary Angiography-Based FFR (caFFR) Measurements: A Multi-Operator Study in Patients with Moderate to Severe Coronary Stenosis

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600129051
Enrollment
Unknown
Registered
2026-07-29
Start date
2026-07-30
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Interventions

Gold Standard:Researcher measurement values (internal reference standards), "internal reference standards" established by experienced researchers
Index test:Non-invasive fractional flow reserve (caFFR), a non-invasive FFR technique based on coronary angiography, was blinded and analyzed by three independent clinical operators using the same sof

Sponsors

Shandong Provincial Hospital (Shandong Children's Hospital)
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. We consecutively enrolled patients aged >=18 years who were undergoing invasive coronary angiography for evaluation of chronic or acute coronary syndrome between November 2023 and May 2024; 2. Eligible patients had at least one major epicardial coronary artery with a visually estimated luminal diameter stenosis of 40% to 90%.

Exclusion criteria

Exclusion criteria: 1. stenosis of the left main coronary artery; 2. ostial stenosis of the right coronary artery; 3. in-stent restenosis of the target vessel; 4. prior coronary artery bypass graft surgery; 5. diffuse coronary artery disease; 6. or ST-segment elevation myocardial infarction within one month.

Design outcomes

Primary

MeasureTime frame
caFFR value;

Countries

China

Contacts

Public ContactYang Xiancun

Shandong Provincial Hospital (Shandong Children's Hospital)

yangxiancun@163.com+86 531 87068890

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Aug 10, 2026