Postoperative nausea and vomiting after total knee arthroplasty
Conditions
Interventions
Opioid-free anesthesia plus dual antiemetic group:Opioid-free general anesthesia combined with dual antiemetics for PONV prophylaxis
Opioid-containing anesthesia routine antiemetic control group:Conventional opioid-containing anesthesia combined with standard clinical dual antiemetic regimen
Opioid-containing anesthesia plus dual antiemetic group:Conventional opioid-containing anesthesia combined with dual antiemetics for PONV prophylaxis
Sponsors
Zigong Fourth People's Hospital(Zigong First-aid Center)
Eligibility
Sex/Gender
Female
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged over 60 years old; 2.ASA physical status ?–?; 3.BMI 18–30 kg/m^2; 4.Having at least three PONV risk factors (female gender, history of motion sickness or PONV, non-smoker, planned postoperative opioid analgesia); 5.Scheduled for elective total knee arthroplasty (TKA).
Exclusion criteria
Exclusion criteria: 1.Sick sinus syndrome, second-degree or higher atrioventricular block, or resting heart rate less than 50 beats per minute; 2.Moderate to severe cardiac, pulmonary, hepatic or renal insufficiency; 3.Parkinson’s disease, Alzheimer’s disease, epilepsy; 4.Pregnancy or lactation; 5.Coagulation disorders; 6.Uncontrolled diabetes mellitus; 7.Glaucoma; 8.Known hypersensitivity to investigational drugs of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative nausea and vomiting within 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative rehabilitation related indicators;Incidence of perioperative drug-related adverse events;Severity of PONV at different postoperative periods and usage rate of rescue antiemetics; | — |
Countries
China
Contacts
Public ContactYu Gu
Zigong Fourth People's Hospital(Zigong First-aid Center)
Outcome results
None listed