Sarcopenia
Conditions
Interventions
Age 30–50 years group:None
Age >50 years group:None
Age <30 years group:None
Sponsors
Shanghai Yangpu District Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18; 2.Patients scheduled to undergo joint-related surgery at Yangpu Hospital, Tongji University School of Medicine; 3.Clinical diagnosis of osteoarthritis, traumatic arthritis, or other non-autoimmune degenerative joint diseases; 4.Availability of joint fluid, articular cartilage, or periarticular muscle tissue samples during surgery; 5.Sample collection does not increase surgical trauma or alter the original surgical plan; 6.Relatively complete clinical data, including demographic information, diagnosis, imaging data, and laboratory results; 7.The participant or legal representative is able to understand the study and voluntarily signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Patients with malignant tumors or suspected malignant tumors; 2.Patients with autoimmune arthritis or rheumatic immune-related joint diseases, such as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, or systemic lupus erythematosus-related arthritis; 3.Patients with severe acute or chronic infection or obvious systemic inflammatory conditions; 4.Patients with severe cardiac, hepatic, renal dysfunction, or coagulation disorders; 5.Recent use of high-dose glucocorticoids, immunosuppressants, or other medications that may significantly affect muscle, bone, or cartilage metabolism; 6.Joint destruction caused by infection, tumor, or other clearly non-degenerative or non-post-traumatic causes; 7.Previous joint replacement, revision surgery, or other surgery at the same site that may significantly affect local tissue status; 8.Pregnant or lactating women; 9.Other conditions judged by the investigator to be unsuitable for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Histopathological score of articular cartilage degeneration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Histomorphological changes in periarticular muscle tissue;Bone mineral density and T-scores of the lumbar spine, femoral neck, and total hip;Ribonucleic acid and protein expression in articular cartilage and periarticular muscle tissue;Imaging features related to joint degeneration;Routine laboratory and bone metabolism parameters;Molecular biomarkers related to musculoskeletal degeneration in whole blood, serum, and synovial fluid;Sarcopenia-related parameters, including handgrip strength, gait speed, muscle mass, and body composition; | — |
Countries
China
Contacts
Public ContactSong Lige
Shanghai Yangpu District Central Hospital
Outcome results
None listed