Type 2 Diabetes Mellitus with Intestinal Mucosal Barrier Dysfunction
Conditions
Interventions
Inflammatory Bowel Disease with Diabetes Mellitus Group:None
healthy control group:None
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for type 2 diabetes mellitus in WHO 1999; 2. Aged 18-65 years, regardless of gender. 3. HbA1c 7%-10%; 4. No prior hypoglycemic drug treatment;
Exclusion criteria
Exclusion criteria: 1. Type 1 diabetes mellitus, gestational diabetes mellitus, or other specific types of diabetes; 2. Comorbid inflammatory bowel disease, intestinal tumors, or other organic intestinal diseases; 3. Use of antibiotics, probiotics, or glucocorticoids within the past 3 months; 4. Pregnant or breastfeeding women; 5. Comorbid severe cardiac, hepatic, or renal insufficiency; 6. Contraindications to colonoscopy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal secretory factors and intestinal mucosal barrier function;Insulin resistance index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum inflammatory cytokines;Intestinal permeability marker;Fasting blood glucose and glycated hemoglobin; | — |
Countries
China
Contacts
Public ContactChangqin Liu
Shanghai Tenth People's Hospital
Outcome results
None listed