Acquired abdominal skin laxity, accompanied by degenerative loss of dermal collagen and elastic fibers, soft tissue sagging
Conditions
Interventions
PLLA injection intervention group:Abdominal subcutaneous layer-by-layer injection of L-lysine lactate for anti-aging treatment. The PLLA was re-dissolved in sterile injection water. One bottle of PLLA
Control Group:There was no PLLA injection intervention in the early stage. The follow-up started from the baseline and lasted until 24 weeks. GAIS scores, dermal thickness measurement by ultrasound, e
Sponsors
Tongji Hospital of Tongji University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Adults aged 18 to 50 years, with previous good health. 2. Abdominal skin laxity assessed by Visual grading of skin sagging as Grade 2/Grade 3 (Hadded et al., 2025). 3. 18.5 kg/m^2 >= BMI >= 24.9 kg/m^2 (Hadded et al., 2025). 4. Good compliance and agreement to complete follow-up. 5. Willing to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Has a major disease such as a history of malignancy, use of anticoagulant drugs, or acute dermatitis at the treatment site, etc. 2. Has delivered a baby within the past 6 months (Benjamin DR, 2014). 3. Is pregnant, breastfeeding, or plans to become pregnant within 1 year. 4. Has previously undergone abdominal contouring surgery. 5. Has received abdominal photoelectric treatments (including laser and light-based devices, radiofrequency energy devices, ultrasound devices, etc.) within the past 1 month. 6. Has received or is expected to receive other injectable products (including biostimulators, collagen, hyaluronic acid, etc.) in the abdominal area within the past 3 months. 7. Has no plans for significant weight loss or major changes in fitness habits within the next 12 months. 8. Has an umbilical hernia detected by abdominal ultrasound examination. 9. Other conditions that the investigator considers unsuitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Global Aesthetic Improvement Scale (GAIS) score of abdominal skin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Abdominal dermal thickness measured via ultrasound;Abdominal skin elasticity tested by Cutometer;The number, frequency and incidence rate of adverse events and adverse reactions;Instances such as equipment breakage and product damage occurred; | — |
Countries
China
Contacts
Public ContactCui Haiyan
Tongji Hospital of Tongji University
Outcome results
None listed