Metabolic dysfunction-associated steatotic liver disease
Conditions
Interventions
Index test:New Ultrasound-based Fat Fraction (UGFF) Technology
Sponsors
The Third Affiliated Hospital Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or older, with risk factors, clinical symptoms, or a prior diagnosis of steatotic liver disease (SLD), including previous imaging findings suggestive of steatosis, or elevated liver function tests accompanied by obesity or diabetes. 2. Have completed or are willing to undergo a liver MRI examination that complies with the technical specifications of this study before the ultrasound (US) examination, and to obtain quantitative proton density fat fraction (PDFF) data. 3. The interval between the ultrasound and MRI examinations should not exceed one month. 4. Able and willing to provide informed consent. 5. Able and willing to undergo a liver ultrasound examination, including fasting, breath-holding, and postural adjustments.
Exclusion criteria
Exclusion criteria: 1. Has advanced chronic liver disease (severe fibrosis; >F3). 2. Has a history of hepatocellular carcinoma or other primary or metastatic malignant liver tumors. 3. Has previously undergone liver surgery (excluding cholecystectomy), including wedge resection, lobectomy, or liver transplantation. 4. Is unable or unwilling to follow the instructions for MRI and ultrasound imaging. 5. Has severe artifacts on liver MRI or ultrasound images that affect the quality of quantitative measurements. 6. Has undergone abdominal surgery between the MRI and ultrasound examinations, or has started or stopped taking medications that may affect liver metabolism during that period. 7. Has experienced significant changes in body weight, diet, or alcohol intake between the MRI and ultrasound examinations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ultrasound examination data: Descriptive data of B-ultrasound images; Doppler measurement data; and quantitative measurement data of SWE and UGFF.;MRI PDFF examination data: MRI images and PDFF measurement results.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Demographic information: Age, gender, ethnicity, relevant medical history and surgical history, including risk factors for liver disease and abdominal surgeries that affect the liver.; | — |
Countries
China
Contacts
Public ContactRen Jie
The Third Affiliated Hospital Sun Yat-sen University
Outcome results
None listed