Patients diagnosed with primary aldosteronism, or those clinically highly suspected of having primary aldosteronism who need further lesion localization and subtype classification.
Conditions
Interventions
Gold Standard:The diagnosis of PA relies on the screening of plasma aldosterone/renin ratio (ARR) and subsequent confirmatory tests, while the classification mainly depends on adrenal venous sampling
Index test:Positron-emitting nuclide-labeled PET/CT imaging targeting CYP11B2. Procedure: IV injection of tracer ? adrenal PET/CT scan ? measurement of PET/CT features. Reference standard: AVS. Image
consensus for disagreements.
Sponsors
Ganzhou People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Voluntary signing of the informed consent form; 2. Age >= 18; 3. Gender: No restrictions; 4. Patients diagnosed with primary aldosteronism as per the "Expert Consensus on Diagnosis and Treatment of Primary Aldosteronism (2024 Edition)".
Exclusion criteria
Exclusion criteria: 1.Severe organ dysfunction (e.g., severe abnormalities of cardiac, hepatic, or renal function). 2.Pregnant or breastfeeding women. 3.Patients with a history of allergy to the radiotracer or its excipients, or those with claustrophobia or other conditions that preclude tolerance of PET/CT scanning. 4.Patients who do not undergo adrenal venous sampling (AVS) within 1 month after PET/CT examination. 5.Patients deemed unsuitable for participation in this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity;Specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| PET/CT features;The SUVmax values of the lesions between the positive and negative groups of primary aldosteronism;The difference in the T/NT value between the lesion and normal tissue; | — |
Countries
China
Contacts
Public ContactLiao Zhongjian
Ganzhou People's Hospital
Outcome results
None listed