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Phosphate Binder Selection, Dosing Interval Adherence, and Suboptimal Anemia Control in Maintenance Hemodialysis Patients on Roxadustat During the Volume-Based Procurement Transition Period: A Case-Control Study

Phosphate Binder Selection, Dosing Interval Adherence, and Suboptimal Anemia Control in Maintenance Hemodialysis Patients on Roxadustat During the Volume-Based Procurement Transition Period: A Case-Control Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600128929
Enrollment
Unknown
Registered
2026-07-28
Start date
2026-08-01
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stage 5 chronic kidney disease (on maintenance hemodialysis) with kidney-related anemia

Interventions

Suboptimal Anemia Control Group:None
Anemia Target-Achievement Group:None

Sponsors

Mindong Hospital of Ningde City
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Age 18 or older; 2. Had been on maintenance hemodialysis before the observation period (before December 1, 2025) for at least 3 months; 3. During the observation period (December 2025 - May 2026), had prescriptions for Roxadustat (Auryxia/BeiRuisheng, etc.) at our outpatient clinic; 4. During the observation period, had at least 2 outpatient Roxadustat prescriptions with a total usage of at least 2 months.

Exclusion criteria

Exclusion criteria: 1. People with malignant tumors (including blood system tumors); 2. Those who only used Rosasosta during hospitalization and didn’t continue it in outpatient care after discharge during the observation period; 3. Those who died or stopped dialysis during the observation period; 4. Those who transferred to another hospital and had no lab records from this hospital for more than a month.

Design outcomes

Primary

MeasureTime frame
Difference in phosphate binder selection (high-risk: sevelamer/calcium acetate vs. low-risk: lanthanum carbonate/none) between the suboptimal anemia control group and the anemia target-achievement gro;Difference in physician order dosing interval labeling rate between the suboptimal anemia control group and the anemia target-achievement group.;

Secondary

MeasureTime frame
Difference in cumulative hospitalization days between the suboptimal anemia control group and the anemia target-achievement group.;Difference in hemoglobin mean value between the suboptimal anemia control group and the anemia target-achievement group.;Difference in combined ESA use proportion between the suboptimal anemia control group and the anemia target-achievement group.;Difference in nursing record dosing interval education documentation rate between the suboptimal anemia control group and the anemia target-achievement group.;

Countries

China

Contacts

Public ContactShu Huang

Mindong Hospital of Ningde City

1183711540@qq.com+86 593 8981211

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Aug 10, 2026