sepsis
Conditions
Interventions
Sepsis group:None
Sponsors
Shandong Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years; 2. Meet the Sepsis-3 diagnostic criteria for sepsis, meaning suspected or confirmed infection with acute organ dysfunction, with a SOFA score increase of >=2 points from baseline; 3. Currently in the ICU and expected to complete at least one bedside HSI collection; 4. The patient or their legal representative/close family member gives informed consent to participate in the study. If the study subjects are limited to septic shock patients, additional criteria: still require vasopressors to maintain mean arterial pressure =65 mmHg after adequate fluid resuscitation, and blood lactate >2 mmol/L. If both sepsis and septic shock patients are included in the study, the shock status should be recorded and described separately during data analysis.
Exclusion criteria
Exclusion criteria: 1.Age <18 years; 2.Pregnant or lactating women; 3.Severe skin defects, burns, wounds, infection, severe edema, dressings, or other conditions at the imaging site that may affect hyperspectral image acquisition or analysis; 4.Arterial catheters, venous catheters, monitoring probes, or other non-removable devices at the imaging site that may interfere with image acquisition; 5.Ongoing resuscitation, examination, transfer, or extremely unstable clinical condition, making research-related imaging inappropriate as judged by the investigator; 6.Expected survival time <48 hours or inability to complete research-related data collection as judged by the investigator; 7.Refusal to participate by the patient or the legally authorized representative/next of kin; 8.Other conditions considered unsuitable for participation by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hyperspectral imaging parameters;Levels of biomarkers related to endothelial glycocalyx injury; | — |
Secondary
| Measure | Time frame |
|---|---|
| lactate;Capillary refill time; | — |
Countries
China
Contacts
Public ContactWei Fang
Shandong Provincial Hospital
Outcome results
None listed