Very Severe Thyroid Eye Disease
Conditions
Interventions
Transorbital approach:Transorbital Orbital Decompression for Patients with Extremely Severe Thyroid Eye Disease
Endonasal approach:Endonasal Orbital Decompression in Extremely Severe TED
Sponsors
Shanghai Ninth Peoples Hospital,Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged 18 years old or above, no gender restrictions; 2.Meeting the diagnostic criteria for extremely severe thyroid eye disease (TED); 3.Failure to respond to or intolerance of conservative treatments (including glucocorticoids, radiotherapy, etc.); 4.Stable euthyroid status within the past six months (including patients under pharmacological control); 5.Voluntary signing of the surgical informed consent form by the patient;
Exclusion criteria
Exclusion criteria: 1.Patients with surgical contraindications including severe cardiac, hepatic or renal insufficiency (myocardial ischemia, myocardial infarction, arrhythmia, cardiac dysfunction), etc. 2.Patients with diabetes mellitus or other autoimmune diseases, uncontrolled hypertension, tuberculosis, or psychiatric disorders; 3.Patients with positive pregnancy test results; 4.Patients whose clinical conditions are unsuitable for combined medial and inferior orbital wall decompression; 5.Candidates planned for the endonasal approach who cannot undergo endoscopic surgery due to abnormal nasal cavity anatomy;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual activity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Operative time;Hospitalization cost;Globe retrodisplacement;Improvement in visual field defect;Ocular motility range;Change in prism diopter deviation;Improvement in diplopia score; | — |
Countries
China
Contacts
Public ContactHuifang Zhou
Shanghai Ninth Peoples Hospital,Shanghai JiaoTong University School of Medicine
Outcome results
None listed