Intracerebral hemorrhage
Conditions
Interventions
Healthy control group:None
Sponsors
Xuanwu Hospital Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for the intracerebral hemorrhage group: (1) Age >= 18 years, gender not restricted; (2) Meet the diagnostic criteria for cerebral hemorrhage, be diagnosed by head CT or MRI, have supratentorial hemorrhage, be an untreated patient without surgery, and have a blood volume of less than 30 mL; (3) Admitted to the hospital within 24 hours after onset; (4) The subject himself or his legal representative/near relative is able to sign the informed consent form. 2. Inclusion criteria for the healthy control group: (1) Age >=18 years, regardless of gender; (2) Participants from the same time period as those undergoing health check-ups at our hospital's Health Examination Center; (3) No history of stroke, intracerebral hemorrhage, cerebral infarction, or other clearly defined organic neurological diseases; (4) No severe active infections, serious immune system disorders, hematological diseases, or end-stage severe organ failure involving heart, liver, kidney, etc.; (5) No acute infection, trauma, or other significant stress conditions within the past two weeks; (6) Able to sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for the intracerebral hemorrhage group: (1) Traumatic intracerebral hemorrhage; (2) Secondary intracerebral hemorrhage caused by conditions such as brain tumors, cerebral vascular malformations, aneurysms, or hemorrhagic transformation of ischemic stroke; (3) Presence of confirmed severe active infection, serious immune system disorders, or hematological diseases; (4) Concurrent end-stage severe organ failure involving heart, liver, kidney, or other organs; (5) Pregnant or breastfeeding women; (6) Any other conditions deemed unsuitable for inclusion in the study by the investigator. 2. Exclusion criteria for the healthy control group: (1) Has a history of previous stroke, intracranial hemorrhage, brain tumor or other severe neurological disorders; (2) Has a clear and severe active infection, severe immune system disease or blood system disease; (3) Has severe organ failure (such as heart, liver, or kidney) at the end stage; (4) Pregnant or lactating women; (5) Other conditions deemed unsuitable for inclusion in this study by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peripheral blood CIRP level; | — |
Secondary
| Measure | Time frame |
|---|---|
| Peripheral blood Cathepsin B level;Imaging indicators including hematoma volume, hematoma location, and perihematomal edema;Inflammatory biomarkers (e.g., IL-6, TNF-a); | — |
Countries
China
Contacts
Public ContactGuohua Wang
Xuanwu Hospital Capital Medical University
Outcome results
None listed