Preeclampsia
Conditions
Interventions
experimental group(150mg):Preventive treatment consisted of 150 mg aspirin taken orally after breakfast each day, with regular monitoring throughout the study period.
Control group(100mg):Preventive treatment consisted of 100 mg aspirin taken orally after breakfast each day, with regular monitoring throughout the study period
Sponsors
Guangdong Province Hospital for Women and Children Healthcare
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Pregnant women (with singleton or twin pregnancies) who underwent preeclampsia screening at 11–13 weeks of gestation and were identified as high-risk; 2. Aged 18 to 45 years; 3. Informed consent: voluntarily participate in this study and have signed a written informed consent form approved by the Ethics Committee.
Exclusion criteria
Exclusion criteria: 1. Pregnant women with known contraindications to aspirin therapy; Presence of severe maternal comorbidities, including: (1) Severe hepatic impairment (ALT or AST > 3× upper limit of normal); (2) Severe renal impairment (eGFR < 60 mL/min/1.73 m²); (3) Uncontrolled hyperthyroidism or hypothyroidism; d. Untreated or poorly controlled infectious diseases (e.g., HIV, syphilis); 3. Prior use of prophylactic aspirin or other antiplatelet medications before randomization; 4. Refusal to participate in follow-up assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of early-onset preeclampsia (defined as diagnosis before 34 weeks of gestation); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of severe maternal complications, including HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet count) and placental abruption;Incidence of early-onset preeclampsia (defined as diagnosis before 34 weeks of gestation);Incidence of gestational hypertension (defined as hypertension without proteinuria or other severe features); | — |
Countries
China
Contacts
Public ContactWu Jing
Guangdong Province Hospital for Women and Children Healthcare
Outcome results
None listed