Colorectal adenoma,carcinoma in situ, adenocarcinoma
Conditions
Interventions
Monotherapy group:Bowel preparation with Oral Sulfate Solution alone.
Combination group:Bowel preparation using lactulose and Oral Sulfate Solution
Sponsors
Bejing Tongren Hospital, Capital Medical Uniersity
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Signed written informed consent approved by the Ethics Committee. 2. Subjects with chronological age between 18 years (inclusive) and 75 years (inclusive), regardless of gender. 3. Self-identified and registered ethnicity as Han or Tibetan. 4. Subjects undergoing colonoscopy for clinical indications. 5. Presence of at least one risk factor for inadequate bowel preparation: (1) Chronic constipation; (2) BMI > 25 kg/m^2; (3) Age > 70 years; (4) History of diabetes mellitus, Parkinson's disease, stroke, or spinal cord injury; (5) Use of tricyclic antidepressants or narcotics.
Exclusion criteria
Exclusion criteria: 1.Refusal to sign or failure to provide informed consent. 2.Use of other medications for bowel preparation. 3.Pregnancy or lactation. 4.Therapeutic colonoscopy, such as polypectomy. 5.Hypersensitivity to any component of sodium magnesium potassium sulfate. 6.Congestive heart failure, severe dehydration, inflammatory bowel disease, known or suspected gastrointestinal perforation, toxic colitis or toxic megacolon, known or suspected intestinal obstruction, known or suspected gastrointestinal obstruction or stricture, gastric emptying disorder, or ascites. 7.Previous colorectal surgery resulting in altered colorectal anatomy unsuitable for bowel preparation quality assessment using the Boston Bowel Preparation Scale (BBPS). 8.Emergency colonoscopy. 9.Severe renal insufficiency (glomerular filtration rate <30 mL/min/1.73m^2). 10.Subjects deemed unsuitable for participation in this study by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bowel preparation success rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient Compliance, Tolerability, and Subjective Feedback;Defecation Characteristics and Intestinal Evacuation Kinetics;Advanced Adenoma Detection Rate;Intraluminal Bubble Elimination Efficacy Assessment;Detection Efficacy Analysis by Adenoma Size;Predictors of Adequate Bowel Preparation;Right-Sided Colon Cleansing Adequacy Rate;Adenoma Detection Rate;The correlation between defecation status and the cleanliness of bowel preparation; | — |
Countries
China
Contacts
Public ContactBin Chuxuan
Bejing Tongren Hospital, Capital Medical Uniersity
Outcome results
None listed