Major Depressive Disorder, MDD
Conditions
Interventions
Control group:modified electroconvulsive therapy, MECT
Experimental group:Esketamine Nasal Spray
Sponsors
The Second General Hospital of Fuzhou Neuropsychiatric prevention and treatment Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–65, any gender; 2. Meet the DSM-5 criteria for major depressive disorder (MDD), diagnosis confirmed using the MINI (Mini International Neuropsychiatric Interview); 3. Have acute suicidal thoughts, which means answering 'yes' to either item B3 ('Have you thought about suicide?') or B10 ('Do you plan to commit suicide within 24 hours?') on the MINI within 24 hours before enrollment; 4. MADRS score >=28, indicating severe depression; 5. Able to understand the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Current or past history of other psychotic disorders (e.g., schizoaffective disorder, bipolar disorder). 2.Current depressive episode with psychotic features. 3.Comorbid severe cardiovascular or cerebrovascular disease, epilepsy, hepatic or renal failure, or other medical conditions precluding MECT or esketamine treatment. 4.Known allergy to esketamine components, or concurrent use of medications with serious drug interactions with esketamine. 5.Pregnant or breastfeeding women. 6.Current substance abuse or alcohol dependence. 7.Inability to comply with and complete the study procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Beck Scale for Suicide Ideation (BSSI);Montgomery–Asberg Depression Rating Scale,MADRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Documentation of suicidal ideation recurrence/behavioral events;IL-17C (Interleukin-17C), CCL-26 (C-C Motif Chemokine Ligand 26), and TG/HDL-C ratio (Triglyceride-to-High-Density Lipoprotein Cholesterol ratio); | — |
Countries
China
Contacts
Public ContactHuang Renchun
The Second General Hospital of Fuzhou Neuropsychiatric prevention and treatment Hospital
Outcome results
None listed