Diabetes mellitus, Cognitive impairment, Dementia
Conditions
Interventions
Normal blood sugar control group:None
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Group A (Diabetic population) (1) Age> = 60 years, no gender restriction; (2) Meeting the World Health Organization (WHO) or American Diabetes Association (ADA) diagnostic criteria: fasting blood glucose >=7.0 mmol/L, or oral glucose tolerance test 2-hour blood glucose >=11.1 mmol/L, or glycated hemoglobin (HbA1c) >=6.5%, or a previously confirmed diagnosis of diabetes and currently receiving hypoglycemic treatment; (3) Have lived in Songjiang District for at least one year and expect to continue living there for the next 10 years; (4) Voluntarily participate and sign the informed consent form. 2. Group B (Normal blood glucose control) (1) Age> = 60 years, no gender restriction (age and gender frequency matching are used for diabetes groups); (2) Fasting blood glucose < 6.1 mmol/L, glycated hemoglobin <6%, no history of diabetes, and no use of any hypoglycemic drugs; (3) Have lived in Songjiang District for at least one year and expect to continue living there for the next 10 years; (4) Voluntarily participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Group A (People with Diabetes) (1) Previously diagnosed with Alzheimer's disease or other types of dementia; (2) History of stroke, brain surgery, or brain injury; (3) Severe mental illnesses (such as schizophrenia or bipolar disorder); (4) Severe vision, hearing, or speech impairments that prevent cooperation with cognitive assessment; (5) Confirmed olfactory disorders (including rhinitis, moderate to severe asthma, nasopharyngeal tumors, nasal deformities, nasal surgery, etc.); (6) Terminal malignant tumors or other serious physical illnesses, with an expected lifespan of less than 2 years; (7) Currently participating in other clinical trials that may affect cognitive function. 2. Group B (Normal Blood Sugar Control Group) (1) People with prediabetes, including fasting blood glucose 6.1-7.0 mmol/L or HbA1c 6.0-6.5%; (2) All other exclusion criteria are the same as for the diabetes group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Annual change in cognitive function score; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of mild cognitive impairment (MCI) or dementia; | — |
Countries
China
Contacts
Public ContactFang Fang
Shanghai General Hospital
Outcome results
None listed