Colorectal cancer
Conditions
Interventions
Control group:Adopting conventional iTME surgery
Experimental group:Adopting a modified iTME procedure that preserves the left colic artery's paraneural plexus through visualization
Sponsors
The Third Affiliated Hospital Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75, of either gender, with a physical fitness status ECOG score of 0-1, and ASA class 1-3; 2. Histopathological examination confirmed rectal adenocarcinoma without distant metastasis; 3. The tumor is located 5-15cm from the anal verge, and laparoscopic iTME anal-preserving surgery is planned, with an expected R0 resection; 4. The anal sphincter function was normal before surgery, and there were no urinary and reproductive system diseases such as urinary dysfunction and erectile dysfunction; 5. Volunteer to join this study, be able to understand the research content and sign a written informed consent form, have good compliance, and be able to complete the full 12-month follow-up.
Exclusion criteria
Exclusion criteria: 1. People who have a history of colorectal surgery, pelvic radiation/surgery, or received neoadjuvant radiotherapy before surgery; 2. Those with severe heart, lung, liver, or kidney problems who can’t handle surgery; 3. People with other cancers, or with mental illnesses or cognitive issues that prevent them from cooperating with the study and follow-ups; 4. Those who, for tumor location, invasiveness, or other reasons, will eventually need a permanent stoma; 5. Other situations where the researcher thinks participation in the study isn’t suitable (like poor compliance or refusal to sign the consent form).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of LARS;Overall Survival Rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| LARS score and incidence rate, Wexner fecal incontinence score, surgery-related indicators, intestinal function recovery indicators, postoperative complication incidence rate, EORTC QLQ-C30 quality of; | — |
Countries
China
Contacts
Public ContactWei Hongbo
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed