stroke
Conditions
Interventions
Dentate Nucleus tTIS Group:Received tTIS intervention targeting the dentate nucleus, 20 minutes per session, 6 days per week, for a total of 12 sessions.
M1 tTIS Group:Received tTIS intervention targeting the primary motor cortex (M1), 20 minutes per session, 6 days per week, for a total of 12 sessions.
Sham tTIS Group:Electrode placement and procedural protocols were identical to those of the active stimulation group, except that current was delivered only briefly at the beginning and end of the ses
Sponsors
The Seventh Affiliated Hospital of Sun Yat-sen University (Shenzhen)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meets the diagnostic criteria for stroke (including cerebral hemorrhage and cerebral infarction) established by the Fourth National Conference on Cerebrovascular Diseases of China. 2. First-ever stroke episode, confirmed by cranial CT or MRI as cerebral hemorrhage or cerebral infarction, with disease duration =1 month. 3. Aged 18–80 years (inclusive), regardless of gender. 4. Stable vital signs. 5. Written informed consent obtained from all patients. 6. Assessed during the screening period by raters who have undergone inter-rater reliability training, with the Brunnstrom stage of the affected upper limb ranging from II to V.
Exclusion criteria
Exclusion criteria: 1. Subjects with cranial defects; 2. Presence of acute or unstable cerebral hemorrhage, large-area cerebral infarction with significant mass effect, active central nervous system infection, or history of epilepsy/epileptiform discharges on EEG; 3. Received electroconvulsive therapy, deep brain stimulation, transcranial magnetic stimulation, or vagus nerve stimulation within the past 7 days; 4. Contraindications for MRI scanning, such as metallic or electronic devices in the body (intracranial metallic foreign bodies, cochlear implants, cardiac pacemakers, etc.); 5. Currently pregnant or lactating, or having plans for pregnancy or childbirth during the trial period; 6. Currently participating in other clinical interventional trials; 7. Other circumstances deemed by the investigator as unsuitable for participation in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the score of Fugl-Meyer Assessment of Upper Extremity; | — |
Secondary
| Measure | Time frame |
|---|---|
| the score of Action Research Arm Test;the score of Montreal Cognitive Assessment;Functional Connectivity;Amplitude of Low-Frequency Fluctuation;Regional Homogeneity;Fractional Anisotropy;Brain Symmetry Index; | — |
Countries
China
Contacts
Public ContactQiang Lin
The Seventh Affiliated Hospital of Sun Yat-sen University (Shenzhen)
Outcome results
None listed