Septic shock
Conditions
Interventions
Methylene blue group:Combined use of methylene blue
Control Group:Guidelines for conventional treatment
Sponsors
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 years old - 80 years old; 2. Transferred to the ICU and met the definition of sepsis 3.0 (septic shock) within 24 hours (confirmed sepsis, persistent hypotension occurred, and vasopressor drugs were still needed to maintain mean arterial pressure (MAP) >= 65 mmHg and blood lactate concentration > 2 mmol/L after adequate volume resuscitation)
Exclusion criteria
Exclusion criteria: 1. Patients who already had AKI or were diagnosed with CKD stage 4-5 upon admission to the ICU; 2. Patients who had used norepinephrine for more than 24 hours; 3. Patients who died within 48 hours; 4. Patients who had undergone kidney or liver transplantation; 5. Pregnant or lactating women; 6. Patients with known glucose-6-phosphate dehydrogenase deficiency; 7. Patients with hemorrhagic, obstructive or hypovolemic shock; 8. Patients with severe burns; 9. Patients allergic to methylene blue, phenothiazine drugs or food dyes; 10. Patients who had recently taken selective serotonin reuptake inhibitors; 11. Patients with pulmonary hypertension, right-to-left shunt, increased right ventricular pressure, severe coronary atherosclerotic heart disease; 12. Patients who refused to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 30-day all-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cardiac function parameters included serum troponin levels, electrocardiographic findings, and echocardiographic assessments.;Renal indicators: requirement for renal replacement therapy within 30 days, serum creatinine levels and urine output, and the incidence and staging of acute kidney injury (AKI).; | — |
Countries
China
Contacts
Public ContactXiangrong Zuo
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Outcome results
None listed