catheter-related bladder discomfort
Conditions
Interventions
Test group :opioid-free anesthesia
Control group:opioid-based anesthesia
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 60 years; 2. A bladder tumor was confirmed via imaging studies (B-ultrasound, CT/MRI) or cystoscopic biopsy, transurethral resection of the bladder tumor (TURBT) is planned. 3. ASA grade ?-?; 4. Preoperative visual analog pain score (VAS) <=3 points; 5. Written informed consent was obtained from all participating patients.
Exclusion criteria
Exclusion criteria: 1. Allergic to the anesthetic agents used in the trial (e.g., propofol, dexmedetomidine, esketamine, rocuronium, etc.) or their excipients; 2. Preoperative moderate to severe pain (VAS> 3) or a history of long-term use of opioids or sedative-analgesic medications (>1 week); 3. Severe arrhythmias such as second-or third-degree atrioventricular block, sick sinus syndrome, or severe bradycardia (heart rate 180/100 mmHg); 5. Severe hepatic or renal dysfunction (e.g. Child-Pugh class C, or an estimated glomerular filtration rate <30 mL/min); 6. Severe cardiovascular diseases (e.g., heart failure, unstable angina); respiratory diseases (e.g., acute exacerbation of chronic obstructive pulmonary disease, respiratory failure); 7. Mental disorders, cognitive dysfunction, or communication impairments; 8. participation in other clinical trials within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of CRBD within 24 hours postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative sedation levels;Intraoperative HR;CRBD severity at 0,1h,2h,6h and 24h postoperatively;the use of vasoactive drugs during the operation;Extubation time;postoperative duration of urinary catheter placement;Occurrence of postoperative adverse events;pain scores at rest at 0,1h,2h,6h and 24h postoperatively;postoperative hospital stays;Intraoperative MAP;Use of analgesics and M-receptor blockers within 24 hours postoperatively;the 15-item quality of recovery (QoR-15) score at 24hour after surgery;eye opening time;time to shift to PACU;PACU stay time;Incidence of CRBD at 0,1h,2h,6h and 24h postoperatively;pain scores during movement at 0,1h,2h,6h and 24h postoperatively; | — |
Countries
China
Contacts
Public ContactXueyuan Yang
Peking University First Hospital
Outcome results
None listed