Obstructive Sleep Apnea Syndrome,OSAS
Conditions
Interventions
Remimazolam Group 2:Continuous intraoperative infusion of remimazolam at 0.4 mg/kg/h
Sodium Chloride Solution Group:Sodium Chloride Solution
Remimazolam Group 1:Continuous intraoperative infusion of remimazolam at 0.2 mg/kg/h
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Male
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age 18 to 65. 2.American Society of Anesthesiologists (ASA) physical status I–III. 3.OSAS patients who are scheduled to undergo UPPP under general anesthesia.
Exclusion criteria
Exclusion criteria: 1.Those who are allergic to the drugs used in the research protocol. 2.Recently, there has been a history of fever and infection. 3.Due to cognitive, language, visual or hearing impairments or having mental illnesses that prevent one from cooperating. 4.Patients who have received systematic psychological treatment within the past three months or are currently taking anti-anxiety or anti-depression medications. 5.History of steroid or non-steroid anti-inflammatory drug use in the past one month. 6.Those with a history of severe respiratory or cardiovascular diseases or those with severely impaired liver and kidney functions. 7.Patients with myasthenia gravis. 8.Refusal to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 score; | — |
Secondary
| Measure | Time frame |
|---|---|
| QoR-15 score;Hospital Anxiety and Depression Scale (HADS) score;The total dosage of remifentanil, propofol and remifentanil used during the operation;MMSE(mini-mental state examination)score;Anesthesia duration;The rates of various adverse events;The incidence of delirium (assessed using the 3D-CAM scale);Satisfaction of doctors, patients or their families;Medication situation:The usage of vasoactive drugs during and after the operation, the situation of postoperative rescue analgesia and antiemesis, and the use of muscle relaxant antagonists;Numerical Rating Scale(NRS) score;Vital signs:Heart rate, non-invasive systolic blood pressure, non-invasive diastolic blood pressure, non-invasive mean arterial pressure, blood oxygen saturation, depth of anesthesia; | — |
Countries
China
Contacts
Public ContactJingjing Yuan
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed