None
Conditions
Interventions
Kidney transplant very early anti-infection treatment observation group:None
Sponsors
Zhongnan Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged >= 18 years old; 2.Patients receiving kidney transplantation within 0–5 days postoperatively; 3.Clinically planned administration of anti-infective agents for perioperative prophylaxis, empirical therapy or confirmed infection treatment, with an anticipated treatment duration of no less than 5 days; 4.Written informed consent obtained from the subject or legal surrogate; 5.Indwelling urinary catheter retained for at least 48 hours postoperatively to facilitate early urine sample collection; 6.Patients anticipated to be free of dialysis requirement with urine output or early graft functional recovery at enrollment.
Exclusion criteria
Exclusion criteria: 1.Previous kidney transplantation or combined multi-organ transplantation; 2.Patients requiring continuous renal replacement therapy in the early postoperative period; 3.Severe hepatic dysfunction, defined as Child-Pugh class C, or ALT/AST > 5 times the upper limit of normal accompanied by markedly elevated bilirubin; 4.Early postoperative use of ECMO, plasmapheresis or other extracorporeal therapies that substantially alter drug clearance; 5.Pregnancy or lactation; 6.Subjects judged inappropriate for enrollment by investigators, including those with unfeasible sampling, extremely short expected survival, severe missing clinical data, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In vivo exposure of anti-infective agents; | — |
Secondary
| Measure | Time frame |
|---|---|
| Conventional renal function markers (Scr, eGFR); | — |
Countries
China
Contacts
Public ContactLing Li
Zhongnan Hospital of Wuhan University
Outcome results
None listed