Liver cancer
Conditions
Interventions
Standard management group:Follow the current clinical routine, which is to do a 24-hour urine protein test only if the urine protein qualitative test is >= 2, and then decide whether to pause targeted
Early active intervention group and Standard management group:When a qualitative urine protein test shows >=1 (or the urine protein/creatinine ratio is >=200 mg/g), the planned intervention should be
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Aged >=18, =3 months; 6.Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pre-existing clinically significant proteinuria (urine protein =1g/24h); 2. Known severe chronic kidney disease (eGFR <60 mL/min/1.73 m²) or need for dialysis; 3. Uncontrolled high blood pressure (systolic =150mmHg or diastolic =100mmHg even after antihypertensive treatment); 4. Use of ACE inhibitors, angiotensin II receptor blockers, or other renin-angiotensin system inhibitors within 4 weeks before the study begins; 5. Having other active malignant tumors; 6. History of kidney transplant; 7. History of asthma; 8. Having long-term cough symptoms; 9. Women who are pregnant or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of dose reduction or interruption of targeted drugs due to proteinuria within one year; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time until clinically significant proteinuria occurs;Changes in kidney function (creatinine, eGFR) compared to baseline;Relative dose intensity of targeted drugs within 1 year;Progression-free survival, overall survival;The occurrence and severity of adverse events (graded according to CTCAE 5.0); | — |
Countries
China
Contacts
Public ContactZhouping Zou
Zhongshan Hospital, Fudan University
Outcome results
None listed