postoperative cognitive function
Conditions
Interventions
R group :reminazolam:Intravenous anesthesia was maintained with reminazolam during the operation.
C group:Ciprofol:Intravenous anesthesia was maintained with ciprofol during the operation.
Sponsors
Fuwai Central China Cardiovascular Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Eligible participants were at least 18 years of age, no gender restriction; 2. Capable of participating in neuropsychological tests and follow-up assessments; 3. American Society of Anesthesiologists (ASA) classification of II–IV and a New York Heart Association (NYHA) functional class of II–IV; 4. Undergoing elective transcatheter heart valve intervention.
Exclusion criteria
Exclusion criteria: 1. Allergic to the investigational drug or contraindicated; 2. Capable of participating in neuropsychological tests and follow-up assessments; 3. Had severe hepatic or renal dysfunction; 4. History of alcohol abuse or drug dependence; 5. Patients were excluded if they had a history of neurological or psychiatric disorders; 6. Who have participated in any clinical drug trial within 1 month prior to screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium at postoperative day 7; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative awakening time;Plasma levels of IL-1ß, IL-6, CRP, and TNF-a;Incidence of postoperative nausea and vomiting;Invasive arterial pressure and mean arterial pressure;Cerebral oxygen saturation during surgery;Number of pacings during surgery;Duration of stay in postanesthesia care unit until discharge; | — |
Countries
China
Contacts
Public ContactLin Hongqi
Fuwai Central China Cardiovascular Hospital
Outcome results
None listed