Burning Mouth Syndrome
Conditions
Interventions
BMS group (within-subject pre–post comparison):Localized sweet stimulation with a glucose solution based on the individual sweet taste threshold
Non-BMS group:N/A
Sponsors
Peking University Hospital of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: BMS Group: 1. Aged 18 years or older; 2. A diagnosis of burning mouth syndrome (BMS) confirmed by at least two experienced oral medicine specialists, based on the Evidence-Based Clinical Practice Guidelines for Burning Mouth Syndrome and the diagnostic criteria of the International Classification of Orofacial Pain (ICOP). All participants must report a burning sensation or pain involving at least the dorsum of the tongue; 3. No evidence of local or systemic conditions that may cause burning mouth symptoms or affect taste function or saliva-related parameters, as determined by medical-history taking; review of previous medical records, examination results, or health examination reports obtained within the previous year; oral examination; and laboratory test results. Relevant conditions include, but are not limited to, iron, folate, or vitamin B12 deficiency; diabetes mellitus; anemia; malignant tumors; gastroesophageal reflux disease; Helicobacter pylori infection; thyroid dysfunction; and oral candidiasis. Non-BMS Group: 1. Aged 18 years or older; 2. No complaint of orofacial pain or unexplained oral discomfort; 3.No obvious oral mucosal lesions on oral examination.
Exclusion criteria
Exclusion criteria: 1.BMS Group: 1. Participants who have communication difficulties or refuse to participate in clinical follow-up; 2. Participants who smoke; 3. Participants with other oral mucosal diseases; 4. Participants who have received antibiotic therapy, immunosuppressive agents, cytotoxic drugs, or glucocorticoids within the previous 2 months; 5. Participants with apparent local oral factors that may affect taste assessment, salivary testing, or the evaluation of oral pain/discomfort, including: (1) Teeth with conditions or local irritants that may cause mucosal pain, such as pulpitis, apical periodontitis, pericoronitis, cracked teeth, residual roots or crowns, sharp cusps, or periodontal abscesses; (2) Severe dentin hypersensitivity (Schiff Cold Air Sensitivity Scale score >= 2 or pain induced by cold stimulation with a visual analogue scale [VAS] score >= 7), or extensive deep carious lesions with sensitivity to cold, sour, or sweet stimuli that precludes taste-threshold testing; 6. Participants with autoimmune diseases; 7. Female participants who are pregnant or breastfeeding. Non-BMS Group: 1. Participants who have communication difficulties or refuse to participate in clinical follow-up; 2. Participants who smoke; 3. Participants with other oral mucosal diseases; 4. Participants with local or systemic factors that may cause oral discomfort, affect taste function, or influence saliva-related parameters, as identified through medical-history taking; review of previous medical records, previous examination results, or health examination reports obtained within the past year; and oral examination; These factors include, but are not limited to, iron, folate, or vitamin B12 deficiency; diabetes mellitus; anemia; malignant tumors; gastroesophageal reflux disease; Helicobacter pylori infection; thyroid dysfunction; and oral candidiasis; Participants with incomplete previous medical information for whom the above conditions cannot be clearly excluded through history screening will not be enrolled in this study. 5. Participants who have received antibiotic therapy, immunosuppressive agents, cytotoxic drugs, or glucocorticoids within the past 2 months. 6. Participants with obvious local oral factors that may affect taste assessment, salivary testing, or the evaluation of oral pain/discomfort, including: (1) Teeth with conditions or local irritants that may cause mucosal pain, such as pulpitis, apical periodontitis, pericoronitis, cracked teeth, residual roots or crowns, sharp cusps, or periodontal abscesses; (2) Severe dentin hypersensitivity, defined as a Schiff Cold Air Sensitivity Scale score >= 2 or a visual analogue scale (VAS) score >= 7 induced by cold stimulation, or extensive deep carious lesions with sensitivity to cold, sour, or sweet stimuli that precludes threshold testing; 7. Participants with autoimmune diseases; 8. Female participants who are pregnant or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sweet taste detection threshold;Change in tongue burning pain intensity assessed by the visual analogue scale (VAS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Salivary physicochemical parameters and related components;Occurrence of study-related adverse events; | — |
Countries
China
Contacts
Public ContactZhimin Yan
Peking University Hospital of Stomatology
Outcome results
None listed