Postoperative delirium, postoperative neurocognitive disorder, perioperative hypotension, postoperative cognitive decline in elderly patients, perioperative hemodynamic disturbance
Conditions
Interventions
All Elderly Surgical Patients group:None
Sponsors
Nanjing Luhe People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age 65 or older, any gender; 2. Planning to undergo elective medium to major surgery under general anesthesia; 3. Expected surgery duration of 60 minutes or more; 4. Patient and immediate family are fully informed about the study details, process, risks, and benefits, and voluntarily sign the informed consent form, agreeing to participate in the entire data collection and follow-up for this study.
Exclusion criteria
Exclusion criteria: 1. Before surgery, the patient had a confirmed history of severe cognitive impairment, Alzheimer's disease, dementia, or serious mental illness; 2. Within six months before surgery, there was a history of strokes, brain hemorrhage, traumatic brain injury, or other organic central nervous system lesions; 3. During surgery, critical adverse events occurred such as massive bleeding, cardiac arrest, severe anaphylactic shock, or persistent severe shock; 4. There were serious hearing or vision problems or speech difficulties, making it impossible to cooperate with pre- or post-surgery cognitive assessments; 5. Clinical records or perioperative monitoring data were severely incomplete, making them insufficient for research analysis; 6. The patient or their family refused to participate in the study or withdrew voluntarily midway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative Mean Arterial Pressure and Spatiotemporal Burden Indicators of Hypotension;Scores of CAM, MMSE and MoCA cognitive function scales; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative regional cerebral oxygen saturation (rSO2);Intraoperative Bispectral Index (BIS) Anesthetic Depth Indicator; | — |
Countries
China
Contacts
Public ContactWang Peng
Nanjing Luhe People's Hospital
Outcome results
None listed