Postoperative pulmonary complications
Conditions
Interventions
DP group:Intraoperative PEEP titration guided by driving pressure
EIT group:Intraoperative PEEP titration guided by electrical impedance tomography
Sponsors
Cancer Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Male and female patients aged between 18 and 80; 2. ASA class =26.
Exclusion criteria
Exclusion criteria: 1. Previous lung or abdominal surgery; 2. Severe lung diseases (like severe COPD); 3. Allergies or contraindications to sevoflurane, propofol, or NSAIDs; 4. BMI over 40 kg/m²; 5. Emergency surgery; 6. Severe brain or cardiovascular dysfunction; 7. Suspected or diagnosed neuromuscular diseases; 8. Expected prolonged mechanical ventilation after surgery; 9. Liver cirrhosis (Child B or C); 10. Chronic kidney failure with dialysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pulmonary complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lung aeration status on postoperative day 3;Postoperative recovery (PACU stay, PONV, time of postoperative defecation or flatus, postoperative hospital stay);Intraoperative ventilation mechanics and lung impedance distribution;NRS score within 3 days postoperatively;Concentrations of biomarkers and inflammatory factors preoperatively, and on POD1 and POD3;Surgical rating scale score intraoperatively; | — |
Countries
China
Contacts
Public ContactTao Yan
Cancer Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed