Severe acute pancreatitis
Conditions
Interventions
Experimental group:Opioid combined with Parecoxib Sodium + conventional treatment group
Control group:Pure Opioid + Routine Treatment Group
Sponsors
The first affiliated hostipal of nanchang university
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Patients aged 18-70 years old; 2.Consistent with the diagnosis of acute pancreatitis (typical abdominal pain, enzymatic and imaging evidence); 3.Patients with severe acute pancreatitis who have had organ failure for more than 48 hours; 4.Within 7 days of onset; 5.Moderate and severe pain, with a pain score of NRS >= 3 points;
Exclusion criteria
Exclusion criteria: 1.Gastric and duodenal ulcers with bleeding; 2.Allergic to parecoxib sodium or opioids; 3.Bronchial asthma or severe chronic obstructive pulmonary disease; 4.Pain of unknown cause; 5.Severe hepatic and renal insufficiency; 6.The patient's condition is critical, with multiple organ failure, and there is a possibility of endotracheal intubation and ventilator-assisted ventilation at any time. 7.Shock cannot be corrected; 8.Pregnant women, lactating women; 9.Patients requiring endotracheal intubation upon admission;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient's pain NRS score;The dosage of opioid drugs required for patients to reach the pain treatment target; | — |
Secondary
| Measure | Time frame |
|---|---|
| All-cause mortality within 28 days;Incidence rate of systemic complications;Serum-related inflammatory factors and related infection indicators;SIRS score;Incidence rate of organ failure; | — |
Countries
China
Contacts
Public ContactXia Liang
The first affiliated hostipal of nanchang university
Outcome results
None listed